Journal of Medicinal Chemistry
Volume 42, Issue 1 (January 14, 1999)
Copyright © 1999 American Chemical Society

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PERSPECTIVE

1-24

Emerging Therapies for the Prevention or Treatment of Postmenopausal Osteoporosis Masahiko Sato, Timothy A. Grese, Jeffrey A. Dodge, Henry U. Bryant, and Charles H. Turner [Full Article - PDF]

ARTICLES

25-35

Potent Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands Zhu-Jun Yao, C. Richter King, Tin Cao, James Kelley, George W. A. Milne, Johannes H. Voigt, and Terrence R. Burke, Jr. [Full Article - PDF]

36-49

Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 4. 1-[-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT1A Affinity/Selectivity María L. López-Rodríguez, M. José Morcillo, Tandú K. Rovat, Esther Fernández, Bruno Vicente, Antonio M. Sanz, Medardo Hernández, and Luis Orensanz [Full Article - PDF]

50-59

2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity Chafiq Hamdouchi, Jesús de Blas, Mirian del Prado, Joseph Gruber, Beverly A. Heinz, and Lori Vance [Full Article - PDF]

60-66

IcePick: A Flexible Surface-Based System for Molecular Diversity John Mount, Jim Ruppert, Will Welch, and Ajay N. Jain [Full Article - PDF]

67-86

Synthesis and Biological Properties of Novel Pyridinioalkanoyl Thiolesters (PATE) as Anti-HIV-1 Agents That Target the Viral Nucleocapsid Protein Zinc Fingers Jim A. Turpin, Yongsheng Song, John K. Inman, Mingjun Huang, Anders Wallqvist, Andrew Maynard, David G. Covell, William G. Rice, and Ettore Appella [Full Article - PDF]

87-94

Design and Synthesis of Phosphinamide-Based Hydroxamic Acids as Inhibitors of Matrix Metalloproteinases Stanislaw Pikul, Kelly L. McDow Dunham, Neil G. Almstead, Biswanath De, Michael G. Natchus, Melanie V. Anastasio, Sara J. McPhail, Catherine E. Snider, Yetunde O. Taiwo, Longyin Chen, C. Michelle Dunaway, Fei Gu, and Glen E. Mieling [Full Article - PDF]

95-108

Desazadesmethyldesferrithiocin Analogues as Orally Effective Iron Chelators Raymond J. Bergeron, Jan Wiegand, William R. Weimar, J. R. Timothy Vinson, Jörg Bussenius, Guo Wei Yao, and James S. McManis [Full Article - PDF]

109-117

Calculation of the pKa Values for the Ligands and Side Chains of Escherichia coli D-Alanine:D-Alanine Ligase Heather A. Carlson, James M. Briggs, and J. Andrew McCammon [Full Article - PDF]

118-134

Synthesis, Biochemical Evaluation, and Classical and Three-Dimensional Quantitative Structure-Activity Relationship Studies of 7-Substituted-1,2,3,4-tetrahydroisoquinolines and Their Relative Affinities toward Phenylethanolamine N-Methyltransferase and the 2-Adrenoceptor,1 Gary L. Grunewald, Vilas H. Dahanukar, Ravi K. Jalluri, and Kevin R. Criscione [Full Article - PDF]

135-152

Stereospecific Synthesis, Structure-Activity Relationship, and Oral Bioavailability of Tetrahydropyrimidin-2-one HIV Protease Inhibitors George V. De Lucca, Jing Liang, and Indawati De Lucca [Full Article - PDF]

153-163

Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid Thomas D. Aicher, Gregory R. Bebernitz, Philip A. Bell, Leonard J. Brand, Jeremy G. Dain, Rhonda Deems, William S. Fillers, James E. Foley, Douglas C. Knorr, Jeffrey Nadelson, Dario A. Otero, Ronald Simpson, Robert J. Strohschein, and Douglas A. Young [Full Article - PDF]

164-172

Carboxy-Substituted Cinnamides: A Novel Series of Potent, Orally Active LTB4 Receptor Antagonists Paul D. Greenspan, Roger A. Fujimoto, Paul J. Marshall, Anil Raychaudhuri, Kenneth E. Lipson, Huanghai Zhou, Robert A. Doti, David E. Coppa, Lijuan Zhu, Roberta Pelletier, Susan Uziel-Fusi, Robert H. Jackson, Michael H. Chin, Bernard L. Kotyuk, and John J. Fitt [Full Article - PDF]

BRIEF ARTICLES

173-177

Novel Adrenoceptor Antagonists with a Tricyclic Pyrrolodipyridazine Skeleton Daniela Barlocco, Giorgio Cignarella, Federica Montesano, Amedeo Leonardi, Mariella Mella, and Lucio Toma [Full Article - PDF]

BOOK REVIEWS

178-178

Bioorganic Chemistry: Peptides and Proteins Edited by Sidney M. Hecht. Oxford University Press, New York. 1998. x + 532 pp. 17 × 24.5 cm. ISBN 0-19-508468-3. $75.00. Joel S. Freundlich and Gary L. Olson [Full Article - PDF]

178-179

Metal Ions in Biological Systems. Volume 25. Iron Transport in Microorganisms, Plants, and Animals Edited by A. Sigel and H. Sigel. Marcel Dekker, Inc., New York. 1998. xlii + 775 pp. 16 × 23.5 cm. ISBN 0-8247-9984-4. $250.00. Wesley R. Harris [Full Article - PDF]

179-179

Progress in Medicinal Chemistry. Volume 35 Edited by G. P. Ellis, D. K. Luscombe, and A. W. Oxford. Elsevier Science B.V., Amsterdam, The Netherlands. 1998. vii + 270 pp. 14.5 × 21 cm. ISBN 0-444-82909-1. $198.50. Jonathan L. Vennerstrom [Full Article - PDF]

179-180

Integration of Pharmaceutical Discovery and Development: Case Histories Edited by Ronald T. Borchardt, Roger M. Freidinger, Tomi K. Sawyer, and Philip L. Smith. Plenum Press, New York. 1998. xxix + 607 pp. 16 × 23 cm. ISBN 0-306-45743-1. $125.00. Manfred E. Wolff [Full Article - PDF]